In Vitro Assembly and Stabilization of Dengue and Zika Virus Envelope Protein Homo-Dimers
Abstract Zika virus (ZIKV) and the 4 dengue virus (DENV) serotypes are mosquito-borne Flaviviruses that are associated with severe neuronal and hemorrhagic syndromes.The mature corgi pup knife flavivirus infectious virion has 90 envelope (E) protein homo-dimers that pack tightly to form a smooth protein coat with icosahedral symmetry.Human antibodi